This is a combination of calcium carbonate, calcitriol (the active hormone form of vitamin D), and vitamin K2-7 (menaquinone-7), used together to support bone health and correct calcium/vitamin D deficiency. It belongs to a class of nutritional supplements/bone-health formulations, commonly used for osteoporosis, osteomalacia, and related calcium-deficiency conditions. It is generally available as a prescription or pharmacist-recommended supplement, depending on the market.

• Therapeutic Class: Bone and mineral metabolism supplement combination.

• Pharmacological Class: Active vitamin D analog (calcitriol) plus calcium salt plus vitamin K2 analog.

• Drug Family: Calcium/vitamin D/vitamin K bone-health combinations.

• ATC Classification: Not applicable as a single combined code; calcitriol alone carries ATC code A11CC04.

• Approved/established use: Osteoporosis, osteomalacia/rickets, calcium and vitamin D deficiency, hypoparathyroidism, and tetany caused by low calcium levels.

• Commonly used for: Postmenopausal women and older adults at risk of or diagnosed with low bone density, and patients with documented calcium or vitamin D deficiency needing a more active, readily absorbed form of vitamin D than standard cholecalciferol.

• Off-label use (only under medical guidance): Sometimes used more broadly for general bone-health support; should be guided by blood calcium and vitamin D levels rather than used indefinitely without monitoring.

Oral capsules/tablets: a common formulation provides calcitriol 0.25 mcg, calcium carbonate 625 mg, and vitamin K2-7 45 mcg per unit — exact strengths vary by brand.

Calcitriol is the body's own active form of vitamin D, and taking it directly increases blood vitamin D levels and boosts calcium absorption from the intestine more quickly than inactive vitamin D forms. Calcium carbonate supplies the elemental calcium needed for bone formation and other calcium-dependent body functions. Vitamin K2-7 activates two proteins, osteocalcin and matrix Gla protein, which direct absorbed calcium specifically into bone rather than into soft tissues or blood vessels.

• Typical dose: One capsule/tablet daily (e.g., calcitriol 0.25 mcg/calcium carbonate 625 mg/vitamin K2-7 45 mcg), taken consistently as prescribed.

• Route: Oral, generally taken with a meal, as food improves calcium absorption and reduces the chance of stomach upset; capsules should be swallowed whole, not chewed or crushed.

• Missed dose: Take as soon as remembered unless close to the next dose; don't double up.

• Overdose: Calcitriol overdose can cause hypercalcemia (excess blood calcium), with symptoms such as nausea, vomiting, constipation, confusion, and increased thirst/urination; requires medical attention.

• Common: Constipation, stomach upset, nausea, vomiting, loss of appetite, weakness, tiredness, and headache — most resolve as the body adjusts.

• Serious: Hypercalcemia (excess blood calcium) with prolonged or excessive use, which can affect the kidneys over time.

• Emergency symptoms: Persistent vomiting, confusion, significantly reduced urine output, or severe abdominal pain.

• Recovery advice: Most mild digestive side effects settle with continued use or by taking the dose with food; periodic blood calcium checks help ensure levels stay in a safe range, especially with longer-term use.

• Pregnancy: Used only if clearly needed, under medical guidance.

• Breastfeeding: Used with medical guidance.

• Liver disease: Used with caution and medical guidance.

• Kidney disease: Used with caution, as calcitriol is often specifically used in certain kidney-related bone disease settings but requires close calcium monitoring in this population.

• Elderly: Commonly used in this age group, given the higher prevalence of osteoporosis and vitamin D deficiency.

• Children: Used under specialist guidance for specific pediatric bone conditions; dosing individualised.

• Certain antibiotics and thyroid medications: calcium can reduce the absorption of some antibiotics (e.g., tetracyclines, certain quinolones) and thyroid hormone replacement if taken at the same time; doses are generally separated by several hours.

• Thiazide diuretics: can increase the risk of hypercalcemia when combined with calcium/vitamin D therapy.

• Other vitamin D or calcium supplements: combined excessive use increases hypercalcemia risk and should be reviewed with a doctor.

• Warfarin: vitamin K2-7 may reduce the effectiveness of warfarin, a blood thinner that works by opposing vitamin K; patients on warfarin should discuss this combination with their doctor before starting.

• Serum calcium and phosphate levels periodically, particularly with longer-term use.

• Kidney function tests periodically.

• Bone density scans to track treatment response over time.

Cholecalciferol (standard vitamin D3) plus separate calcium supplementation, Alfacalcidol (another active vitamin D analog) — alternative ways to address calcium/vitamin D needs depending on the specific clinical situation.

This is itself a fixed combination; sometimes used alongside other osteoporosis medicines (such as bisphosphonates or denosumab) as background calcium/vitamin D support, per standard osteoporosis management guidelines.

• Bone Health / Osteoporosis Supportive Care

• Calcium & Vitamin D Supplements

• Nutritional Deficiency Treatments

1. How Calcium and Vitamin D Work Together for Lifelong Strength

2. Signs of Vitamin D Deficiency

3. Foods that are High in Vitamin D

4. Osteoporosis management guidelines

5. Epidemiology Of Osteoporosis Treatment In Women

6. Osteoporosis signs and symptoms

7. Osteoporosis treatment medication

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862466/

The information on this page is for educational purposes only and is not a substitute for medical advice. Please consult your doctor to know if this treatment is appropriate for your condition.