Nublexa 40 mg tablet is used in the treatment of:

• Colorectal cancer has started to spread to other parts of the body
• Gastrointestinal stromal tumors (GIST) (a type of stomach and bowel cancer)
• Liver cancer in adult patients who have already undergone treatment with Sorafenib

Nublexa 40 mg tablets work by slowing down the growth and spread of cancer cells and cutting off their blood supply.

Inform your doctor about all the prescribed medicines, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you take or have taken before the treatment. Certain drugs may interact with Nublex 40 mg tablet and cause undesirable side effects. Concurrent use of this tablet and CYP3A4 inhibitors like ketoconazole (oral) and others may interact with this medicine.

Keep this medicine out of sight and reach of children. Do not use it after the expiration date.

Follow the exact dosage prescribed by your doctor. Do not crush, chew or break the tablet. Swallow the tablet as a whole with water. Take the tablet with food.

Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.

Severe:

• Allergic reaction
• Severe liver problems
• Bleeding
• Gastrointestinal perforation
• Infections
• Heart attack and severe chest pain
• Severely high blood pressure
• Skin eruptions
• Pancreatitis
• Skin cancers
• Confusion, Seizures, headaches, and vision loss with or without high blood pressure
• Stevens-Johnson syndrome
• Skin detachment
• Enlargement of a blood vessel or a tear in a blood vessel

Common:

• Reduced number of white blood cells
• Hypothyroidism
• Lowered levels of phosphate, potassium, calcium, sodium, or magnesium
• Elevated level of uric acid in the blood
• Dehydration
• Headache and tremors
• Disorder of the nerves that causes numbness, tingling, weakness, or pain (peripheral neuropathy)
• Changes in taste, dry mouth
• Heartburn
• Gastroenteritis (inflammation and infection of the stomach)
• Hair loss (alopecia)
• Dry skin
• Rashes
• Muscle spasms
• Protein in urine
• Abnormal blood clotting condition

Talk to the doctor if the patient has any liver disorders, infection, bleeding problems, stomach and bowel problems, chest pain, heart diseases, high blood pressure, persistent headache, seizures, or recently had or going to have a surgical procedure before taking this medicine. It is not recommended for adolescents and children. Avoid drinking grapefruit juice while taking this medicine, as it can use the effectiveness of the medications. Avoid taking this medicine if the patient is planning for pregnancy or during pregnancy and breastfeeding, as it causes harmful effects on the developing baby.

1. Bayer AG; Electronic Medicines Compendium; [Revised:2019] [Accessed:29/Apr:2021] https://www.medicines.org.uk/emc/files/pil.1263.pdf
2. TJ Ettrich et al; Regorafenib; [Revised:2014] [Accessed:29/Apr/2021] https://pubmed.ncbi.nlm.nih.gov/24756792/
3. Dirk Strumberg; Regorafenib for cancer; [Revised:2012] [Accessed:29/Apr/2021] https://pubmed.ncbi.nlm.nih.gov/22577890/
4. Bayer HealthCare Pharmaceuticals Inc; US Food And Drug Administration; [Revised:2012] [Accessed:29/Apr/2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203085lbl.pdf