• Colorectal cancer has started to spread to other parts of the body
• Gastrointestinal stromal tumors (GIST) (a type of stomach and bowel cancer)
• Liver cancer in adult patients who have already undergone treatment with Sorafenib (anticancer medicine)

Regdual 40mg Tablet binds to tyrosine kinase receptors and inhibits the VEGF (vascular endothelial growth factor) and EGFR (epidermal growth factor receptor) receptors on the cell surface. By binding to these receptors, this medication blocks an important pathway that promotes cell division. This helps to prevent the growth and multiplication of cancer cells.

Inform your doctor about all the prescription medications, over-the-counter drugs, vitamins, and herbal supplements you are taking or have taken before starting treatment with Regdual 40mg Tablet. Certain medications may interact with Regdual 40mg, potentially causing adverse effects. For example, the concurrent use of CYP3A4 inhibitors such as ketoconazole and certain antibiotics may alter the effectiveness of Regdual or increase the risk of side effects. Always consult your healthcare provider before combining therapies.

• Keep this medicine out of sight and reach of children.
• Store at room temperature between 20°C to 25°C.

Always take this medicine exactly as your doctor has told you. Swallow the tablets whole with water. Do not crush or chew the tablets. Avoid drinking grapefruit juice while taking this medicine.

Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.

Severe:

• Liver problems (yellowish discoloration of skin and whites of the eyes, dark urine, confusion)
• Bleeding
• Infection (high fever, cough with or without sputum, pain when urinating, unusual vaginal discharge, shortness of breath)
• Stomach and bowel problems (severe stomach pain, blood in vomit, red or black stools)

Common: 

• Low blood cell count
• Decreased appetite, weight loss
• Nausea, vomiting
• High blood pressure
• Voice changes
• Diarrhea
• Dry mouth, painful tongue, mouth sores
• Changes in liver function
• Weakness, lack of energy
• Pain, redness, blisters and swelling of palms of the hands or soles of the feet
• Dehydration
• Hair loss, dry skin
• Headache
• Heartburn
• Low levels of potassium, phosphate, calcium, sodium or magnesium in blood
• Shaking
• Numbness, tingling
• Taste disorders
• Muscle spasms
• Abnormal clotting condition
• Protein in the urine

Before starting Regdual 40mg Tablet, inform your doctor if you have any liver conditions, infections, bleeding problems, heart diseases, high blood pressure, stomach or bowel issues, or are undergoing surgery. This medication is not recommended for children and adolescents. Avoid consuming grapefruit juice while on Regdual, as it may reduce the drug's effectiveness. Women who are pregnant, planning pregnancy, or breastfeeding should avoid using this medicine due to the potential harm to the developing baby. Always consult your doctor for guidance.

1. Bayer AG; Electronic Medicines Compendium; [Revised:2019] [Accessed:29/Apr:2021] https://www.medicines.org.uk/emc/files/pil.1263.pdf
2. TJ Ettrich et al; Regorafenib; [Revised:2014] [Accessed:29/Apr/2021] https://pubmed.ncbi.nlm.nih.gov/24756792/
3. Dirk Strumberg; Regorafenib for cancer; [Revised:2012] [Accessed:29/Apr/2021] https://pubmed.ncbi.nlm.nih.gov/22577890/
4. Bayer HealthCare Pharmaceuticals Inc; US Food And Drug Administration; [Revised:2012] [Accessed:29/Apr/2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203085lbl.pdf