REGONAT 40MG TABLET

Introduction:

Regonat 40mg Tablet is a targeted therapy containing the active constituent regorafenib. It is used to treat colon cancer, rectal cancer, liver cancer, and gastrointestinal stromal tumors (GIST) (a type of cancer of the stomach and bowel). Cancer is a disorder in which cells multiply in an uncontrolled and abnormal manner. 

Talk to your doctor if you have any liver disorders, infection, bleeding problems, stomach and bowel problems, chest pain, heart diseases, high blood pressure, persistent headache, seizures, or if you recently had or going to have a surgical procedure before taking this medicine. Regonat 40mg Tablet is not recommended for adolescents and children. 

Avoid drinking grapefruit juice while taking this medicine, as it can affect the way this medicine works. Use effective birth control during the treatment and for at least eight weeks after the last dose. Talk to your doctor if you are on a salt-controlled diet as Regonat 40mg Tablet contains sodium.

Uses of Regonat 40mg Tablet:

• Colorectal cancer has started to spread to other parts of the body
• Gastrointestinal stromal tumors (GIST) (a type of stomach and bowel cancer)
• Liver cancer in adult patients who have already undergone treatment with Sorafenib (anticancer medicine)

How Regonat 40mg Tablet works:

Regonat 40mg Tablet binds to tyrosine kinase receptors and inhibits the VEGF (vascular endothelial growth factor) and EGFR (epidermal growth factor receptor) receptors on the cell surface. By binding to these receptors, this medication blocks an important pathway that promotes cell division. This helps to prevent the growth and multiplication of cancer cells.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep this medicine out of sight and reach of children. 
• Store below 30°C.

References:

1. Bayer plc, Electronic medicines compendium (emc), [Revised on August 2021] [ Accessed on 5th August 2021], https://www.medicines.org.uk/emc/files/pil.1263.pdf
2. Bayer Healthcare Pharmaceuticals Inc, US Food and Drug Administration, [Revised on April 2018] [ Accessed on 5th August 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203085lbl.pdf
3. Thomas J Ettrich, Thomas Seufferlein; Regorafenib; Recent Results in Cancer Research; Published on 2014; Accessed on 01/12/2021; https://pubmed.ncbi.nlm.nih.gov/24756792/
4. Dirk Strumberg, Beate Schultheis; Regorafenib for cancer; Expert Opinion on Investigational Drugs; Published on June 2012; Accessed on 01/12/2021; https://pubmed.ncbi.nlm.nih.gov/22577890/

How to use Regonat 40mg Tablet:

Always take this medicine exactly as your doctor has told you. Swallow the tablets whole with water. Do not crush or chew the tablets. Avoid drinking grapefruit juice while taking this medicine.

Safety advice:

Pregnancy:

This medicine is not safe to be used in pregnancy. Consult with your doctor for advice.

Breastfeeding:

It is not recommended to breastfeed while taking Regonat 40mg Tablet. Consult with your doctor for advice.

Liver:

Regonat 40mg Tablet should be used with caution in patients suffering from liver diseases. Consult with your doctor for advice.

Others:

Inform your doctor if:

• You have an infection, bleeding problems, stomach and bowel problems, chest pain, heart diseases, high blood pressure, persistent headache, or seizures.
• You recently had or going to have a surgical procedure.

Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects; not everyone gets them.

Severe:

• Liver problems (yellowish discoloration of skin and whites of the eyes, dark urine, confusion)
• Bleeding
• Infection (high fever, cough with or without sputum, pain when urinating, unusual vaginal discharge, shortness of breath)
• Stomach and bowel problems (sever stomach pain, blood in vomit, red or black stools)

Common:

• Low blood cell count
• Decreased appetite, weight loss
• Nausea, vomiting
• High blood pressure
• Voice changes
• Diarrhea
• Dry mouth, painful tongue, mouth sores
• Changes in liver function
• Weakness, lack of energy
• Pain, redness, blisters and swelling of palms of the hands or soles of the feet
• Dehydration
• Hair loss, dry skin
• Headache
• Heartburn
• Low levels of potassium, phosphate, calcium, sodium or magnesium in blood
• Shaking
• Numbness, tingling
• Taste disorders
• Abnormal clotting condition
• Protein in the urine
• Muscle spasms

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