palbace 125 mg uses are:

• Treatment of hormone receptor (HR)-positive.

• Human epidermal growth factor 2 (HER2)-negative advanced or metastatic breast cancer. 

Palbace 125mg Tablet works by blocking the protein called cyclin-dependent kinases 4 and 6, which are vital for the division and growth of cells. By blocking these proteins, this medication slows the growth and prevents the cancer cells from spreading. 

Inform your doctor about all medications including prescribed, over-the-counter, nutritional or vitamin supplements and herbal products that you are taking or have taken before the treatment. Concurrent use of palbociclib with CYP3A4 inhibitors such as fentanyl has reported increased fentanyl toxicity. certain medications may interact with the effectiveness of this drug.

• Keep Palbace 125mg Tablet out of sight and reach of children.
• Store at 20°C to 25°C.

Take Palbace 125mg Tablet exactly as prescribed by your doctor. Take this medication once a day at the same time with food. Swallow this capsule as a whole with a glass of water. Avoid crushing, breaking, or chewing the capsule. 

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. palbace 125 mg side effects are 

Serious:

• Blood disorder (fever, chills, shortness of breath, weakness, bleeding, or bruising)
• Lung inflammation (chest pain, dry cough, or difficulty breathing)

Common:

• Tiredness
• Hair loss
• Dry skin, rash
• Infections
• Low blood cell counts
• Decreased of appetite
• Nausea, vomiting
• Diarrhea
• Swelling of lips and mouth
• Changes in taste
• Nose bleed
• Dry eye, blurred vision, increased tearing

• Avoid grapefruit, grapefruit juice, and products containing St. John’s wort during Palbace 75mg treatment.

• Use effective birth control while on treatment:

  • For females → continue for at least 3 weeks after the last dose.

  • For males → continue for at least 14 weeks after the last dose.

• This medicine may reduce fertility; consult your physician if you have concerns.

• Your doctor may recommend regular blood tests to monitor the effect of Palbace 125mg Tablet on blood cells.

1. Pfizer Labs, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 26 Nov 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf
2. Neha S Mangini et al; Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer; The Annals of Pharmacotherapy; Published on Nov 2015; Accessed on 26/11/2022; https://pubmed.ncbi.nlm.nih.gov/26324355/
3. Palbace; Pfizer; Revised on Oct 2021; Accessed on 26/11/2022; https://labeling.pfizer.com/ShowLabeling.aspx?id=14029