Semabrex 8 mg is used for:

• Improving blood glucose control in adults with type 2 diabetes mellitus

• Managing type 2 diabetes along with diet and exercise

The doctor decides the appropriate dose and duration of treatment.

Semabrex 8 mg contains semaglutide, which mimics the action of GLP-1, a hormone involved in blood glucose regulation.

It stimulates insulin release when blood glucose levels are elevated and reduces glucagon secretion. It also slows gastric emptying and can reduce appetite. These effects help improve blood glucose control in people with type 2 diabetes.

Tell your doctor about all medicines you take before starting Semabrex 8 mg.

• Insulin or sulfonylureas: Using semaglutide with these medicines can increase the risk of low blood sugar. Their doses may need adjustment.

• Oral medicines: Semaglutide can delay gastric emptying and may affect the absorption of medicines taken by mouth.

• Warfarin or other coumarin medicines: Your doctor may recommend closer INR monitoring when semaglutide treatment is started.

• Other semaglutide-containing medicines or GLP-1 receptor agonists: Do not use these together with Semabrex unless specifically advised by your doctor.

• Store Semabrex in a refrigerator at 2°C to 8°C.

• Do not freeze.

• Keep the medicine protected from light.

• Keep it out of reach of children.

• Follow the storage instructions provided on the product packaging.

• Semabrex 8 mg is administered as an injection under the skin (subcutaneous injection).

• Semaglutide injections are generally given once a week, on the same day each week, as prescribed by your doctor.

• It can be injected into the abdomen, thigh or upper arm.

• Do not inject it into a vein or muscle.

• Use only the dose prescribed by your doctor. Do not change the dose or frequency yourself.

• If the product is supplied as a vial, use it only according to the instructions provided with the product and by your healthcare professional.

Semabrex may cause gastrointestinal side effects, particularly when treatment is started or the dose is increased.

Common side effects

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal pain

• Decreased appetite

• Indigestion

• Headache

• Dizziness

Serious side effects

Contact your doctor promptly if you develop:

• Severe or persistent abdominal pain, which may indicate pancreatitis

• Persistent vomiting or diarrhoea with signs of dehydration

• Symptoms of low blood sugar, particularly when using insulin or a sulfonylurea

• Sudden changes in vision

• Symptoms of a serious allergic reaction, such as swelling of the face or throat or difficulty breathing

• Severe abdominal pain that may indicate gallbladder problems

• Use Semabrex exactly as prescribed by your doctor.

• Take your weekly injection on the same day each week.

• Rotate injection sites between the abdomen, thigh and upper arm.

• Do not inject into a vein or muscle.

• Do not change the dose without medical advice.

• Drink enough fluids, particularly if you experience vomiting or diarrhoea.

• Tell your doctor if you use insulin or sulfonylureas because your risk of low blood sugar may increase.

• Inform your doctor if you have a history of pancreatitis, gallbladder disease, diabetic eye disease or severe gastrointestinal problems.

• Tell your healthcare team that you use semaglutide before undergoing general anaesthesia or deep sedation.

• Follow the product-specific instructions for preparing and administering the injection.