Semabrex may be used for:

• Improving blood glucose control in adults with type 2 diabetes mellitus

• Managing type 2 diabetes along with diet and exercise

The doctor decides the appropriate dose and duration of treatment.

Semabrex contains semaglutide, which mimics the action of GLP-1, a hormone involved in blood glucose regulation.

It stimulates insulin release when blood glucose levels are elevated and reduces glucagon secretion. It also slows gastric emptying and can reduce appetite. These effects help improve blood glucose control.

Tell your doctor about all medicines you take before starting Semabrex.

• Insulin or sulfonylureas: Using semaglutide with these medicines can increase the risk of low blood sugar. Their doses may need adjustment.

• Oral medicines: Semaglutide can delay gastric emptying and may affect the absorption of some medicines taken by mouth.

• Warfarin or other coumarin medicines: Your doctor may recommend closer monitoring of blood clotting when semaglutide treatment is started.

• Other semaglutide-containing medicines or GLP-1 receptor agonists: Do not use them together with Semabrex unless specifically advised by your doctor.

• Store Semabrex in a refrigerator at 2°C to 8°C.

• Do not freeze.

• After first use, the semaglutide injection vial can be stored for 42 days when kept at a temperature not exceeding 30°C or refrigerated at 2°C to 8°C.

• Protect the vial from heat and light.

• Keep it out of reach of children.

• Dispose of the vial after the applicable 42-day period following first use.

• Semabrex is administered as a subcutaneous injection.

• The pack states that it is administered once weekly.

• Use the dose prescribed by your doctor.

• The product is supplied as a multi-dose vial.

• Use the disposable syringe supplied with the pack as instructed by your doctor or healthcare professional.

• The pack contains one vial, four disposable syringes and four alcohol swabs.

• Do not reuse a disposable syringe or share your syringe with another person.

• Do not change the dose or injection frequency on your own.

• Follow the instructions provided with the product for handling and administration.

Semabrex may cause gastrointestinal side effects, particularly when treatment is started or the dose is increased.

Common side effects

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal pain

• Decreased appetite

• Indigestion

• Headache

• Dizziness

Serious side effects

Contact your doctor promptly if you develop:

• Severe or persistent abdominal pain, which may indicate pancreatitis

• Persistent vomiting or diarrhoea with signs of dehydration

• Symptoms of low blood sugar, particularly when using insulin or a sulfonylurea

• Sudden changes in vision

• Symptoms of a serious allergic reaction, such as swelling of the face or throat or difficulty breathing

• Severe abdominal pain that may indicate gallbladder problems.

• Use Semabrex exactly as prescribed by your doctor.

• Take your injection on the same day each week.

• Use the disposable syringe supplied with the product as directed.

• Do not reuse or share a disposable syringe.

• Rotate injection sites as instructed by your healthcare professional.

• Do not change the prescribed dose or injection frequency yourself.

• Keep the vial refrigerated at 2°C to 8°C before use.

• After first use, keep the vial according to the stated storage conditions and discard it after 42 days.

• Tell your doctor if you use insulin or a sulfonylurea because your risk of low blood sugar may increase.

• Inform your doctor if you have a history of pancreatitis, gallbladder disease, diabetic eye disease or severe gastrointestinal problems.