Wyntide 0.25mg/0.5mg Pen Injection is used:

• To improve blood sugar control in adults with type 2 diabetes mellitus

• Along with diet and exercise as part of diabetes management

Your doctor will decide the indication, dose and duration of treatment based on your medical condition and response to treatment.

Wyntide contains semaglutide, which mimics the action of the naturally occurring hormone glucagon-like peptide-1 (GLP-1).

It activates GLP-1 receptors and helps control blood glucose by:

• Increasing insulin release when blood glucose levels are high

• Reducing glucagon release when blood glucose levels are high

• Slowing gastric emptying, which can help reduce the rise in blood glucose after meals

These effects help improve blood sugar control.

Tell your doctor about all medicines you take before starting Wyntide.

• Insulin and sulfonylureas: Using semaglutide with these medicines can increase the risk of low blood sugar. Your doctor may adjust their dose.

• Medicines taken by mouth: Semaglutide delays gastric emptying and may affect the absorption of some medicines taken by mouth.

• Warfarin and other coumarin medicines: Additional monitoring may be needed when semaglutide is started in people taking these medicines.

• Other GLP-1 receptor agonists: Do not use Wyntide with another semaglutide-containing medicine or another GLP-1 receptor agonist unless specifically prescribed.

• Before first use, store Wyntide in a refrigerator at 2°C to 8°C.

• Do not freeze.

• Do not store the pen directly next to the refrigerator cooling element.

• After first use, the pen can be stored for 56 days at 15°C to 30°C or at 2°C to 8°C.

• Discard the pen 56 days after first use, even if some medicine remains.

• Keep the pen cap on when not in use to protect it from light.

• Keep out of the sight and reach of children.

Wyntide 0.25mg/0.5mg Pen Injection is administered as a subcutaneous injection, meaning it is injected under the skin.

• It is generally injected into the abdomen, thigh or upper arm.

• It is administered once a week as prescribed by your doctor.

• It can be administered at any time of the day, with or without food.

• The 0.25 mg dose is generally used when starting treatment.

• The dose may then be increased to 0.5 mg according to your doctor's instructions.

• The Wyntide pen delivers doses in 0.25 mg or 0.5 mg increments only.

• Use a new needle for each injection.

• The pack contains six needles.

• Do not share the pen with another person.

• Do not inject Wyntide into a vein or muscle.

• Follow the dose and schedule prescribed by your doctor.

Wyntide may cause digestive side effects, particularly when treatment is started or the dose is increased.

Common side effects

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal pain

• Decreased appetite

• Indigestion

• Headache

• Dizziness

Serious side effects

Seek medical attention if you develop:

• Severe or persistent abdominal pain, which may indicate pancreatitis

• Severe vomiting or diarrhoea with signs of dehydration

• Symptoms of low blood sugar, particularly when using insulin or a sulfonylurea

• Sudden changes in vision

• Signs of a serious allergic reaction

• Symptoms of gallbladder disease

• Use Wyntide exactly as prescribed by your doctor.

• The 0.25 mg dose is generally used to start treatment, followed by gradual dose escalation.

• Do not increase the dose yourself.

• Use Wyntide once weekly on the day prescribed by your doctor.

• It can be administered with or without food.

• Rotate injection sites as instructed by your healthcare professional.

• Use a new needle for every injection.

• Do not share the pen with another person.

• Keep the pen cap on when the pen is not in use to protect it from light.

• Discard the pen 56 days after first use, as stated on the Wyntide packaging.

• Tell your doctor if you have a history of pancreatitis, gallbladder disease, diabetic eye disease or severe gastrointestinal problems.

• Tell your doctor if you use insulin or a sulfonylurea because the risk of low blood sugar may be increased.

• Inform your healthcare team that you use semaglutide before surgery or deep sedation.