Livarise 15mg Cartridge 3ml is used for:

• Chronic weight management in adults with obesity.

• Chronic weight management in adults who are overweight and have at least one weight-related health condition.

• Management of type 2 diabetes mellitus in adults when prescribed for this indication, along with diet and exercise.

For weight management, it should be used together with a reduced-calorie diet and increased physical activity.

Semaglutide acts like GLP-1, a hormone involved in appetite and blood glucose regulation. It acts on GLP-1 receptors in areas involved in appetite control, helping reduce hunger and food intake.

It also slows gastric emptying and can increase feelings of fullness after eating. In people with type 2 diabetes, semaglutide also helps regulate blood glucose by increasing insulin release when blood glucose levels are elevated and reducing glucagon secretion.

Together, these effects can support weight management and improve blood glucose control.

Tell your doctor about all medicines you take before using Livarise.

• Insulin and sulfonylureas: Using semaglutide with these medicines can increase the risk of hypoglycaemia. Your doctor may need to adjust their doses.

• Other semaglutide-containing medicines: Do not use Livarise together with another medicine containing semaglutide.

• Other GLP-1 receptor agonists: Combining Livarise with another GLP-1 receptor agonist is not recommended.

• Oral medicines: Semaglutide delays gastric emptying and may affect the absorption of medicines taken by mouth. Tell your doctor if you take medicines that require close monitoring.

• Store Livarise in a refrigerator at 2°C to 8°C.

• Do not freeze the medicine.

• Do not use it if it has been frozen.

• Protect the cartridge and pen from direct light.

• Keep the medicine out of the sight and reach of children.

• After first use, follow the product instructions for storing the reusable pen. The current Indian product information states that the pen can be stored below 30°C or in a refrigerator at 2°C to 8°C after first use.

Livarise is administered once a week as a subcutaneous injection. It can be injected into the abdomen, thigh or upper arm. It can be administered at any time of day, with or without food. Try to use it on the same day each week.

The dose is usually started at a lower level and increased gradually according to the treatment plan prescribed by the doctor. The 15mg/3mL cartridge describes the total amount of semaglutide in the cartridge and does not mean that 15mg is given as a single injection.

Use the reusable pen only as instructed by your doctor or the product instructions. Remove and safely dispose of the needle after each injection. Do not share the pen with another person.

The most common side effects of Livarise include:

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal discomfort

These effects are particularly common when treatment is started or the dose is increased and may become less troublesome as the body adjusts to treatment.

Contact your doctor if you experience severe or persistent abdominal pain, repeated vomiting, symptoms of dehydration or changes in vision. Seek immediate medical attention if you develop symptoms of a serious allergic reaction.

• Use Livarise exactly as prescribed by your doctor.

• Do not assume that the 15mg cartridge means a 15mg weekly dose. The cartridge contains 15mg in total.

• Follow the prescribed dose-escalation schedule.

• Use the injection on the same day each week.

• Follow the reduced-calorie diet and physical activity plan recommended by your healthcare professional.

• Smaller meals may help if you experience nausea or early fullness.

• Maintain adequate fluid intake, particularly if you experience vomiting or diarrhoea.

• Rotate injection sites to reduce local irritation.

• Remove the needle after every injection.

• Never share the reusable pen with another person.

• Tell your healthcare team that you use semaglutide before surgery or deep sedation.