Semabest 2mg Injection is used to:

• Improve blood sugar control in type 2 diabetes mellitus: It may be used alone when metformin-based treatment is considered inappropriate because of intolerance or contraindications.

• Support additional blood sugar control: It may be added to other medicines used for type 2 diabetes.

Semabest is not used to treat type 1 diabetes or diabetic ketoacidosis.

Semabest 2mg Injection contains Semaglutide, which activates GLP-1 receptors.

It stimulates insulin secretion when blood sugar is high and reduces glucagon secretion. It also delays stomach emptying, particularly after meals, helping improve blood sugar control.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, supplements and herbal products you take.

• Insulin or sulfonylureas: May increase the risk of hypoglycaemia when used with Semaglutide.

• Oral medicines: Delayed stomach emptying may affect the rate at which some oral medicines are absorbed.

• Other GLP-1 receptor agonists: Do not combine Semabest with another GLP-1 receptor agonist unless specifically prescribed.

• Warfarin or other coumarin derivatives: Closer INR monitoring may be needed when Semaglutide is started.

• Store Semabest 2mg Injection in a refrigerator at 2°C to 8°C.

• Do not freeze.

• Do not use if the pen has been frozen.

• Protect the pen from light.

• Keep out of the sight and reach of children.

• Follow the product-specific storage instructions after first use.

Use Semabest 2mg Injection exactly as prescribed.

Semaglutide treatment is usually started at 0.25mg once weekly. After 4 weeks, it may be increased to 0.5mg once weekly. After at least 4 weeks at 0.5mg, the dose may be increased to 1mg and then 2mg once weekly if additional blood sugar control is needed.

Semabest is injected under the skin of the abdomen, thigh or upper arm once weekly, at any time of the day, with or without food.

The 2mg in the pen is the total amount of Semaglutide in the pen and is not automatically the weekly dose.

Do not inject it into a vein or muscle. Follow the instructions supplied with the prefilled pen and do not share the pen or needles.

If a dose is missed, administer it within 5 days. If more than 5 days have passed, skip it and resume the next dose on the regular day.

Common side effects of Semabest 2mg Injection may include:

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal pain

• Indigestion

• Abdominal distension

• Headache

• Dizziness

Serious side effects:

• Severe and persistent abdominal pain, which may indicate pancreatitis.

• Severe allergic reactions, including swelling of the face, lips, tongue or throat or difficulty breathing.

• Persistent vomiting or diarrhoea, which may cause dehydration.

• Sudden loss of vision, requiring urgent ophthalmological assessment.

• Worsening diabetic retinopathy, particularly in patients receiving insulin.

• Low blood sugar, particularly when used with insulin or sulfonylureas.

• A neck lump, persistent hoarseness, difficulty swallowing or difficulty breathing, which should be medically assessed.

Seek medical attention promptly if serious symptoms occur.

• Use Semabest exactly as prescribed.

• Do not assume the 2mg pen contains a 2mg weekly dose.

• Follow the gradual dose-escalation schedule given by your doctor.

• Keep your diabetes monitoring appointments.

• Tell your doctor if you have diabetic retinopathy.

• Stay hydrated if vomiting or diarrhoea occurs.

• Do not share the pen or needles.

• Tell your doctor before surgery or deep sedation.

• Seek urgent medical attention for severe abdominal pain or sudden vision loss.