Semabest 4mg Injection is used to:

• Improve blood sugar control in type 2 diabetes mellitus: It may be used as monotherapy when metformin-based treatment is considered inappropriate because of intolerance or contraindications.

• Support additional blood sugar control: It may be added to other medicines used for type 2 diabetes.

Semabest is not used for type 1 diabetes or diabetic ketoacidosis.

Semabest 4mg Injection contains Semaglutide, which activates GLP-1 receptors.

It increases insulin secretion when blood glucose is high and reduces glucagon secretion. Semaglutide also delays stomach emptying, particularly after meals, which contributes to its blood sugar-lowering effects.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, supplements and herbal products you take.

• Insulin or sulfonylureas: May increase the risk of low blood sugar when combined with Semaglutide.

• Oral medicines: Delayed stomach emptying may affect the rate of absorption of some oral medicines.

• Other GLP-1 receptor agonists: Do not combine Semabest with another GLP-1 receptor agonist unless specifically prescribed.

• Warfarin or other coumarin derivatives: Your doctor may recommend closer INR monitoring after starting Semaglutide.

• Store Semabest 4mg Injection at 2°C to 8°C in a refrigerator.

• Do not freeze.

• Do not use if frozen.

• Protect the pen from light.

• Keep out of the sight and reach of children.

• Follow the product-specific instructions for storage after first use.

Use Semabest 4mg Injection exactly as prescribed.

The usual starting dose of Semaglutide is 0.25mg once weekly. After 4 weeks, it may be increased to 0.5mg once weekly. After at least 4 weeks at 0.5mg, the dose may be increased to 1mg once weekly and then to 2mg once weekly when additional blood sugar control is needed.

Semabest is injected under the skin of the abdomen, thigh or upper arm once a week, at any time of the day, with or without food.

The 4mg in the pen is the total product content and is not a 4mg weekly dose.

Do not inject into a vein or muscle. Follow the instructions for the prefilled pen and do not share the pen or needles.

If you miss a dose, administer it within 5 days. If more than 5 days have passed, skip it and resume the regular weekly schedule.

Common side effects of Semabest 4mg Injection may include:

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal pain

• Indigestion

• Abdominal distension

• Headache

• Dizziness

Serious side effects:

• Severe, persistent abdominal pain, which may indicate pancreatitis.

• Severe allergic reactions, including swelling of the face, lips, tongue or throat or difficulty breathing.

• Persistent vomiting or diarrhoea, which may cause dehydration.

• Sudden loss of vision, requiring urgent medical assessment.

• Worsening diabetic retinopathy, particularly in patients taking insulin.

• Low blood sugar, particularly with insulin or sulfonylureas.

• A neck lump, persistent hoarseness, difficulty swallowing or difficulty breathing, which requires medical assessment because of the thyroid C-cell tumour warning associated with Semaglutide.

Seek medical attention promptly if serious symptoms occur.

• Use Semabest exactly as prescribed.

• Do not confuse the 4mg pen strength with your weekly dose.

• Follow the gradual dose-escalation schedule prescribed by your doctor.

• Keep diabetes monitoring appointments.

• Tell your doctor if you have diabetic retinopathy.

• Stay hydrated if you experience vomiting or diarrhoea.

• Do not share your pen or needles.

• Tell your doctor before surgery or deep sedation.

• Seek urgent medical attention for severe abdominal pain or sudden vision loss.