Semalix 8 Pen Injection is indicated for the treatment of adults with insufficiently controlled type 2 diabetes mellitus, alongside diet and exercise.

• Helps improve blood glucose control in adults with type 2 diabetes.

• May be used alone when metformin-based treatment is unsuitable because of intolerance or contraindications.

• May be used alongside other medicines for type 2 diabetes when additional blood glucose control is needed.

Your doctor will decide whether this medicine is suitable for you and determine the appropriate dose and duration of treatment.

Semalix 8 contains semaglutide, which mimics the action of the naturally occurring GLP-1 hormone.

It activates GLP-1 receptors and helps regulate blood glucose by stimulating insulin release when blood glucose is high and reducing glucagon secretion. It also delays gastric emptying to some extent, which can slow the rise in blood glucose after meals.

These actions help improve blood glucose control in people with type 2 diabetes.

Tell your doctor about all the medicines you take before starting Semalix 8 Pen Injection.

• Insulin and sulfonylureas: Using semaglutide with these medicines can increase the risk of low blood glucose. Your doctor may need to adjust their doses.

• Warfarin and other coumarin anticoagulants: More frequent monitoring of blood clotting parameters may be required when semaglutide treatment is started.

• Oral medicines: Semaglutide delays gastric emptying and may affect how quickly certain medicines taken by mouth are absorbed. Inform your doctor if you take medicines that require rapid absorption.

• Other medicines for diabetes: Your blood glucose levels may need closer monitoring when semaglutide is added to your existing treatment.

• Before first use, store the unopened pen in a refrigerator at 2°C to 8°C.

• Do not freeze the medicine. Do not use it if it has been frozen.

• After first use, the pen can be stored for 56 days at 15°C to 30°C or in a refrigerator at 2°C to 8°C.

• Discard the pen 56 days after first use, even if some medicine remains.

• Keep the pen cap on when it is not in use to protect the medicine from light.

• Keep the pen away from excessive heat and out of the reach of children.
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• Use Semalix 8 Pen Injection only as prescribed by your doctor.

• It is administered as a subcutaneous injection, usually into the abdomen, thigh or upper arm.

• Semaglutide is generally administered once weekly, at any time of the day, with or without food.

• Treatment usually begins with 0.25mg once weekly for four weeks, followed by 0.5mg once weekly. The dose may then be increased to 1mg and subsequently 2mg at intervals of at least four weeks, depending on blood glucose control and tolerability.

• The 0.25mg dose is a starting dose, not a maintenance dose. Weekly doses above 2mg are not recommended for this diabetes treatment regimen.

• Follow the instructions supplied with the pen and use a new needle for each injection.

• Rotate injection sites and never share the pen or needle with another person.

• Do not inject the medicine into a vein or muscle.

Your doctor will determine the dose and any dose changes based on your response to treatment.

Semalix 8 Pen Injection may cause side effects, particularly when treatment begins or the dose increases. Gastrointestinal symptoms are among the most commonly reported effects.

Common side effects

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal discomfort or pain

• Bloating

• Indigestion

• Reduced appetite

These effects may improve as your body adjusts to treatment. Eating smaller meals and maintaining adequate fluid intake may help manage mild gastrointestinal symptoms.

Serious side effects

Seek medical attention if you experience any of the following:

• Severe, persistent abdominal pain: This may indicate pancreatitis, particularly if the pain spreads to the back or occurs with vomiting.

• Severe allergic reactions: Swelling of the face, lips, tongue or throat, or difficulty breathing, requires emergency medical attention.

• Severe dehydration: Persistent vomiting or diarrhoea can cause dehydration and may affect kidney function.

• Sudden changes or loss of vision: These symptoms require prompt medical assessment, particularly in people with diabetic retinopathy.

• Low blood glucose: Sweating, shaking, dizziness, confusion or weakness may occur, especially when semaglutide is used with insulin or sulfonylureas.

• Symptoms of thyroid tumours: Report a lump in the neck, persistent hoarseness, difficulty swallowing or breathing to your doctor. Semaglutide is contraindicated in people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2).

• Follow your prescribed weekly schedule and do not change the dose without medical advice.

• Do not use Semalix 8 as a starting dose simply because the pen contains 8mg in total. Treatment begins at a lower dose and increases gradually.

• Monitor your blood glucose as recommended by your doctor.

• If you use insulin or a sulfonylurea, ask your doctor whether your existing doses need adjustment.

• Eat balanced meals and maintain regular physical activity to support diabetes management.

• Drink enough fluids, especially if you experience vomiting or diarrhoea.

• Inform your doctor about any history of pancreatitis, diabetic retinopathy or thyroid-related conditions before starting treatment.

• Tell your healthcare team that you use semaglutide before surgery or a procedure involving general anaesthesia or deep sedation.

• Never share your pen with another person, even if you change the needle.

• Discard the pen 56 days after first use, even if some medicine remains.