Usema 4mg Injection is used to:

• Improve blood sugar control in type 2 diabetes mellitus: It helps lower blood glucose levels when used along with diet and exercise.

• Support long-term diabetes management: It may be used alone or with other diabetes medicines when additional blood sugar control is needed.

Usema is not used to treat type 1 diabetes or diabetic ketoacidosis.

Usema 4mg Injection contains Semaglutide, which acts like the natural hormone GLP-1 involved in blood sugar regulation.

It increases insulin release when blood sugar levels are high and reduces the release of glucagon, a hormone that raises blood sugar. Semaglutide also slows stomach emptying and can increase feelings of fullness, which may reduce food intake.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, supplements, and herbal products you take.

• Insulin or sulfonylureas: Using Semaglutide with insulin or medicines such as glimepiride or gliclazide can increase the risk of low blood sugar. Your doctor may adjust the dose of these medicines.

• Oral medicines: Semaglutide slows stomach emptying and may affect the absorption of some medicines taken by mouth. Tell your doctor if you take medicines that require close monitoring.

• Warfarin or other coumarin medicines: Closer monitoring may be needed when Semaglutide is started or the dose is changed.

• Other GLP-1 receptor agonists: Do not use Usema with another Semaglutide-containing medicine or another GLP-1 receptor agonist unless specifically prescribed by your doctor.

• Store Usema 4mg Injection in a refrigerator at 2°C to 8°C before use.

• Do not freeze Usema or store it close to the freezer compartment.

• Do not use the medicine if it has been frozen.

• Protect the pen from light.

• Keep Usema out of the sight and reach of children.

• Follow the storage instructions on the product packaging after the pen is first used.

Use Usema 4mg Injection exactly as prescribed by your doctor.

The 4 mg/3 mL pen is designed to deliver a 1 mg dose of Semaglutide. It is injected under the skin once a week, usually on the same day each week. It may be given at any time of the day, with or without food.

Inject Usema into the abdomen, thigh, or upper arm. Rotate injection sites when possible. Do not inject it into a vein or muscle.

Your doctor may gradually increase the Semaglutide dose depending on your blood sugar control and how well you tolerate the medicine.

Do not share the pen or needles with another person. Use a new needle for each injection if your device requires a separate needle.

Common side effects of Usema 4mg Injection may include:

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal pain

• Decreased appetite

• Indigestion

• Headache

• Dizziness

• Fatigue

These effects are more likely when treatment is started or the dose is increased and may become less noticeable as the body adjusts.

Serious side effects:

• Severe or persistent abdominal pain, sometimes spreading to the back, which may indicate pancreatitis.

• Persistent vomiting or diarrhoea that may cause dehydration and kidney problems.

• Gallstones or inflammation of the gallbladder, which may cause abdominal pain, fever or yellowing of the skin or eyes.

• Severe allergic reactions such as swelling of the face, lips, tongue or throat or difficulty breathing.

• Severe low blood sugar, particularly when Usema is used with insulin or a sulfonylurea.

• Sudden or worsening changes in vision, particularly in people with diabetic eye disease.

• Severe gastrointestinal symptoms, particularly in people with problems with delayed stomach emptying.

Seek medical attention if you develop symptoms of a serious reaction.

• Use Usema exactly as prescribed by your doctor.

• Do not change the dose or stop treatment without medical advice.

• Follow your recommended diet and physical activity plan.

• Drink enough fluids, particularly if you experience vomiting or diarrhoea.

• Tell your doctor if you have diabetic retinopathy or develop changes in your vision.

• Tell your doctor if you have severe problems with delayed stomach emptying.

• Tell your doctor before surgery or a procedure requiring general anaesthesia or deep sedation.

• Tell your doctor if you have a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.

• Never share your pen with another person.

• Seek medical attention if you develop severe or persistent abdominal pain.